Drug & Medicine Update from epgonline.org

Nebivolol 5 mg tablets

Hypertension Treatment of essential hypertension. Chronic heart failure (CHF) Treatment of stable mild and moderate chronic heart failure in addition to standard therapies in elderly patients of 70 years or older.

TRACTOCILE injection

TRACTOCILE is indicated to delay imminent pre-term birth in pregnant women with: ? regular uterine contractions of at least 30 seconds duration at a rate of 4 per 30 minutes ? a cervical dilation of 1 to 3 cm (0-3 for nulliparas) and effacement of 50% ? age 18 years ? a gestational age from 24 until 33 completed weeks ? a normal fetal heart rate

Tarivid IV Infusion Solution

Ofloxacin is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms. It is indicated for the treatment of the following infections when caused by sensitive organisms: Lower Respiratory Tract: Acute and chronic infections. Upper and Lower Urinary Tract: Acute and chronic lower urinary tract infections; acute and chronic upper urinary tract infections (pyelonephritis). Septicaemia. Skin and soft tissue infections. Microbiological results indicate that the following pathogens may be regarded as sensitive: Staphylococcus aureus (including methicillin resistant staphylococci), Staphylococcus epidermidis, Neisseria species, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Hafnia, Proteus (indole-negative and indole-positive strains), Salmonella, Shigella, Acinetobacter, Yersinia enterocolitica, Campylobacter jejuni, Aeromonas, Plesiomonas, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydiae, Legionella, Gardenerella. Variable sensitivity is shown by Streptococci, Serratia marcescens, Pseudomonas aeruginosa, Clostridium species and Mycoplasmas. Anaerobic bacteria (e.g. Fusobacterium species, Bacteroides species, Eubacterium species, Peptococci, Peptostreptococci) are normally resistant. Tarivid is not active against Treponema pallidum.

Rebif 8.8 mg injection

Rebif is indicated for the treatment of relapsing multiple sclerosis. In clinical trials, this was characterised by two or more acute exacerbations in the previous two years. Efficacy has not been demonstrated in patients with secondary progressive multiple sclerosis without ongoing relapse activity

Rebif 44mg injection

Qlaira

Oral contraception.

Denzapine

DENZAPINE is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severe, untreatable neurological adverse reactions to other antipsychotic agents, including atypical antipsychotics. Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agents, including an atypical antipsychotic agent, prescribed for adequate duration. DENZAPINE is also indicated in psychotic disorders occurring during the course of Parkinson's disease, in cases where standard treatment has failed.

Firmagon

FIRMAGON is a gonadotrophin releasing hormone (GnRH) antagonist indicated for treatment of adult male patients with advanced hormone-dependent prostate cancer.

Ondansetron 2 mg/ml Injection.

Management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, and for the prevention and treatment of post-operative nausea and vomiting (PONV).

IXIARO

IXIARO® is indicated for active immunization against Japanese encephalitis for adults. IXIARO® should be considered for use in individuals at risk of exposure through travel or in the course of their occupation.

Hypoloc 5 mg tablets

Alli 60 mg hard capsules

Alli is indicated for weight loss in adults who are overweight (body mass index, BMI, 28 kg/m2) and should be taken in conjunction with a mildly hypocaloric, lower-fat diet.

Berinert

Hereditary angioedema type I and II (HAE) Treatment of acute episodes

Indipam XL

Essential hypertension

Extavia

Extavia is indicated for the treatment of • Patients with a single demyelinating event with an active inflammatory process, if it is severe enough to warrant treatment with intravenous corticosteroids, if alternative diagnoses have been excluded, and if they are determined to be at high risk of developing clinically definite multiple sclerosis (see section 5.1). • Patients with relapsing-remitting multiple sclerosis and two or more relapses within the last two years. • Patients with secondary progressive multiple sclerosis with active disease, evidenced by relapses.

Solpadeine Max Soluble Tablets

Solpadeine Max Soluble Tablets are recommended for the relief of mild to moderate pain, for example, headache (including migraine), sinusitis, dental pain, arthritic and rheumatic pain, sciatica, lumbago, sprains and strains and dysmenorrhoea. It may also be used to relieve the pain and febrile symptoms of influenza.

Sevikar

Treatment of essential hypertension. Sevikar is indicated in patients whose blood pressure is not adequately controlled on olmesartan medoxomil or amlodipine monotherapy

Binocrit

Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients: - Treatment of anaemia associated with chronic renal failure in paediatric and adult patients on haemodialysis and adult patients on peritoneal dialysis. - Treatment of severe anaemia of renal origin accompanied by clinical symptoms in adult patients with renal insufficiency not yet undergoing dialysis. Treatment of anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, preexisting anaemia at the start of chemotherapy). Binocrit can be used to increase the yield of autologous blood from patients in a predonation programme. Its use in this indication must be balanced against the reported risk of thromboembolic events. Treatment should only be given to patients with moderate anaemia (haemoglobin (Hb) 10 � 13 g/dl [6.2 � 8.1 mmol/l], no iron deficiency), if blood saving procedures are not available or insufficient when the scheduled major elective surgery requires a large volume of blood (4 or more units of blood for females or 5 or more units for males). Binocrit can be used to reduce exposure to allogeneic blood transfusions in adult noniron deficient patients prior to major elective orthopaedic surgery, having a high perceived risk for transfusion complications. Use should be restricted to patients with moderate anaemia (e.g. Hb 10 - 13 g/dl) who do not have an autologous predonation programme available and with an expected blood loss of 900 to 1800 ml.

Calcipotriol

Calcipotriol Ointment 50micrograms/g is indicated for the topical treatment of mild to moderately severe psoriasis (psoriasis vulgaris).

Ipocol 400mg MR Tablets

To treat mild to moderate ulcerative colitis and maintain ulcerative colitis in remission.

Clindamycin 150mg Capsules

Antibacterial. Serious infections caused by susceptible Grampositive organisms, staphylococci (both penicillinase- and nonpenicillinase-producing), streptococci (except Streptococcus faecalis) and pneumococci. It is also indicated in serious infections caused by susceptible anaerobic pathogens. Clindamycin does not penetrate the blood/brain barrier in therapeutically effective quantities.

AlphaNine

Treatment and prophylaxis of bleeding in patients with haemophilia B (congenital Factor IX deficiency).

Luvinsta

Treatment of primary hypercholesterolaemia and mixed hyperlipidaemia (Fredrickson Types IIa and IIb) as an adjunct to diet when response to diet and other non-pharmacological treatments is inadequate. Luvinsta is also indicated in patients with coronary heart disease for the secondary prevention of coronary events (cardiac death, non-fatal myocardial infarction and coronary revascularisation) after percutaneous coronary intervention,

Atripla

Atripla is a fixeddose combination of efavirenz, emtricitabine and tenofovir disoproxil fumarate. It is indicated for the treatment of human immunodeficiency virus1 (HIV1) infection in adults with virologic suppression to HIV1 RNA levels of < 50 copies/ml on their current combination antiretroviral therapy for more than three months. Patients must not have experienced virological failure on any prior antiretroviral therapy and must be known not to have harboured virus strains with mutations conferring significant resistance to any of the three components contained in Atripla prior to initiation of their first antiretroviral treatment regimen. The demonstration of the benefit of Atripla is primarily based on 48week data from a clinical study in which patients with stable virologic suppression on a combination antiretroviral therapy changed to Atripla. No data are currently available from clinical studies with Atripla in treatmentnaïve or in heavily pretreated patients. No data are available to support the combination of Atripla and other antiretroviral agents.

Politid XL 75mg Prolonged-release Capsules

Major depressive episodes. • Short-term treatment of generalised anxiety disorder. • Short-term treatment of social anxiety disorder/ social phobia • Treatment of panic disorders, with or without agoraphobia.

Politid XL 150mg Prolonged-release Capsules

Goddard's Embrocation

For the symptomatic relief of muscular pain and stiffness, including backache, sciatica, lumbago, fibrositis, rheumatic pain and pain caused by bruises, sprains, strains, stiff muscles and unbroken chilblains.

Eno

The symptomatic relief of indigestion, flatulence and nausea.

Piriteze Allergy Syrup

Adults and children aged 6 years and over. Symptomatic treatment of allergic rhinitis (seasonal and perennial), and chronic idiopathic urticaria

Pepto-Bismol, 17.5mg/ml oral suspension

For upset stomach, indigestion, heartburn and nausea. Controls diarrhoea.

Panadol ActiFast

Panadol ActiFast is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine and tension headaches, toothache, neuralgia, backache, rheumatic and muscle pains, dysmenorrhoea, sore throat, and for relieving the fever, aches and pains of colds and flu.

Pepto-Bismol Chewable Tablets

For fast relief of upset stomach, indigestion, heartburn and nausea. Controls diarrhoea.

Original Andrews Salts

The product is recommended as a laxative and as an antacid for the relief of upset stomach, indigestion and biliousness

Sensodyne Mint

Macleans Sensitive/Sensodyne Mint is recommended for the relief of tooth sensitivity and the prevention of dental caries.

Quellada-M Liquid

Eradication of head lice, pubic lice and their eggs. Treatment of scabies.

Andrews Plus+

Recommended for the relief of headache with gastric upset, particularly associated with over-indulgence in food or drink or both.

Beechams All-In-One Tablets

Short term symptomatic relief of colds, chills and influenza including chesty coughs.

Methotrexate 25mg/ml solution for Injection (hameln)

Methotrexate 25 mg/ml solution for injection may be used for the following indications: • Chronic polyarthritis (rheumatoid arthritis), severe, generalised psoriasis vulgaris resistant to therapy, including psoriatic arthritis. • Acute lymphocytic leukaemias (ALL). • Prophylaxis and treatment of meningeal leukaemia (intrathecal administration). • Non-Hodgkin's lymphomas. • Cancer of the ovary. • Head and neck cancer. • Breast cancer. • Choriocarcinoma and similar trophoblastic diseases. • Cancer of the cervix. • Bronchogenic carcinoma. • Osteosarcoma. • Mycosis fungoides. • Cancer of the bladder.

Zantac 75 Tablets

Symptomatic relief of heartburn, indigestion, acid indigestion and hyperacidity. For prevention of acid indigestion, indigestion, hyperacidity and heartburn associated with consuming food and drink. The product is not indicated in the following patients without seeking their doctor's or pharmacist's advice: • Patients with renal and/or hepatic impairment. Patients under regular medical supervision for other reasons. • Patients suffering from any other illness or taking medications either physician prescribed or self prescribed. • Patients of middle age or older with new or recently changed symptoms of indigestion. • Patients with unintended weight loss in association with symptoms of indigestion.

Freederm Treatment 4% w/w Gel

For the topical treatment of mild to moderate inflammatory acne vulgaris